Fullmetal Alchemist Episode 1
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Summary (From Wikipedia):
In a brief flashback, the Elric brothers Edward and Alphonse had attempted to perform an alchemical transmutation in the hopes of bringing their late mother back to life, but they had failed in doing so. As a consequence, Al disappears, Ed loses his left leg, and a grotesque figure appears in the transmutation circle. In the present, the brothers walk across a desert. They arrive at Lior, where they hear about a religious leader named Father Cornello who can create miracles. However, as they realize that he is performing alchemy and ignoring the law of equivalent exchange, they believe that he possesses the philosopher's stone, which they had been searching for to restore Al's body. Threatened, Cornello orders Cray to kill them. Rosé, a girl the brothers meet, is traumatized after witnessing Al's lack of a human body, runs to Cornello. The Elrics follow her, and Cornello releases a chimera on them when they meet. Cornello also transmuted a giant bird from a parrot and sends it to fight against Ed, who fends both of the chimera and the bird off by exposing his automail, his metal arm and leg. Cornello then realizes why Ed is nicknamed the "Fullmetal Alchemist", understanding that the brothers had committed the ultimate sin of human transmutation.